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KMID : 0361019980410091164
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 9 p.1164 ~ p.1168
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Differences of Nasal Hypersensitivity between Smokers and Nonsmokers
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김영도/Young Doe Kim
조중생/장도영/홍남표/차창일/Joong Saeng Cho/Do Young Jang/Nam Pyo Hong/Chang Il Cha
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Abstract
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Background and Objectives: Smoking is regarded as one of the factors that bring about nonspecific hypersensitivity in allergic nasal mucosa. But it is uncertain how chronic smoking affects hypersensitivity in nasal mucosa. This study was
designed
to evaluate the relationship between smoking and nasal hypersensitivity. In this study, histamine is used since it is commonly used to evaluate nasal hypersensitivity.
Material and Methods: Twelve smokers and 9 nonsmokers were participated
in
this study. Nasal mucosae of each subjects were stimulated by thiorphan followed by substance P. After stimulation, several dilutions of 10 to 5×104 ㎍/㎖ of histamine was instilled to both nasal cavity at intervals of 10 minutes. We
measured the volume of nasal cavity by acoustic rhinometry in each step and counted the number of sneezing and nasal blowing at every 10 minute intervals. Changes in volume after each dillutions of histamine instillations were compared with the
values
measured after the stimulation by thiorphan and substance P., and this value was expressed as the percentage volume change.
Results: The nasal volume of smoker group was increased upto 100 ㎍/㎖ of histamine and decreased from 1000 ㎍/㎖
of
histamine. The nasal volume of nonsmoker group decreased more than the smoker group with each dilution of histamine. The number of sneezing and nasal blowing increased in each group with each dilution of histamine.
Conclusions: Chronic
smoking
may decrease susceptibility of hypersensitivity to histamine in nasal mucosa.
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KEYWORD
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